Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway. | 最新消息 - 中國醫藥大學附設醫院

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Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway.

最新消息

2018/7/20

Curcumin induces cell apoptosis in human chondrosarcoma through extrinsic death receptor pathway.

李湘萍 Hsiang-Ping Lee 醫師

軟骨肉瘤是一種軟組織肉瘤，對預後不良，對常規化療無反應。手術治療導致嚴重殘疾，局部復發率和生命威脅率很高。發現薑黃素誘導人軟骨肉瘤細胞系（JJ012和SW1353）的凋亡。薑黃素誘導軟骨肉瘤細胞中Fas，FasL和DR5表達的上調。最重要的是，動物研究顯示治療21天后腫瘤體積顯著減少60％。薑黃素可能是一種治療軟骨肉瘤的新型抗癌藥物。

詳細資料：

https://www.ncbi.nlm.nih.gov/pubmed/22522053

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